Gene Editing Principles and Applications

B.D. Singh · N.S. Shekhawat

Scientific Publishers

About this ebook

Gene or genome editing is barely two decades old, but its impact is palpable in every discipline of biological sciences, especially basic and applied biomedical researches. It enables a planned and precise alterations in genome sequences as well as controlled activation or repression of selected gene functions. Base editors based on CRISPR-Cas system were created a couple of years ago, and they permit permanent conversion of the single targeted base pair into another base pair. The potential of this powerful discipline are testified by its contributions in the form of gene therapies of otherwise intractable human diseases and improved crop varieties with novel traits.

The present book is designed to provide the basic principles of gene editing as well describe its realized and potential applications. The book targets biologists in general and geneticists, biomedical researchers and plant breeders in particular. It is hoped that it will be useful to post-graduate students, research scholars and research workers concerned with analyses of biological phenomena and development of strains with novel and useful traits.

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About the author

Dr. Brahma Deo Singh, M.Sc. (Kanpur University), Ph.D. (University of Saskatchewan, Canada) was Emeritus Professor, School of Biotechnology, Banaras Hindu University (BHU), Varanasi, India. He joined the university in 1973 and has been teacher, active researcher, mentor of several scientists/scholars. Dr. Singh has published over 150 research papers in reputed journals, and has authored over two dozen books in the areas of plant breeding, genetics, and biotechnology. Some of his very popular books are Plant Breeding: Principles and Methods (10th edn), Genetics (3rd edn), Fundamentals of Genetics (4th edn), Biotechnology (5th edn), Biotechnology: Expanding Horizons (4th edn), and Plant Biotechnology (3rd edn). His books Padap Prajanan: Siddhant Evam Vidhiyan, and Anuvanshiki Ke Adhar were awarded the first prize of the Dr Rajendra Prasad Puraskar of ICAR, New Delhi. His book Marker Assisted Plant Breeding; Principles and Practices (2015, Springer) has been well received internationally.

Dr. Narpat Singh Shekhawat retired as Professor of Botany (UGC-Center for Advanced Studies in Botany) after a dedicated tenure of 36 years of teaching at the Jai Narain Vyas University, Jodhpur. During this period he served as Head of the Botany Department, in-charge of the Biotechnology Unit/DBT Network project, and coordinator of the UGC-SAP/COSIST and DST-FIST programs in Botany. Prof. Shekhawat has published over 125 research papers in journals of repute and has co-edited the book Plant Tissue Culture and Molecular Markers: Their Role in Improving Crop Productivity. He has taught Cell biology, Genetics, Molecular biology and plant breeding to M.Sc. (Botany) students. He has been Post-doctoral Research Associate at Department of Biology, Yale University, recipient of Biotechnology Overseas Research Associateship of DBT, Government of India, and worked at the University of Minnesota, St. Paul, USA as visiting scientist in plant genomics. He has been mentor for Ph.D./M.Phil. Students/post-doctoral fellows/young scientists/UNESCO-Keizo Obuchi fellow, and served as National Correspondent (India Chapter) of International Association of Plant Biotechnology (IAPB). He is member of State Higher Education Council of Rajasthan.